Severe Mycobacterial and Salmonella Infections in Interleukin-12 Receptor-Deficient Patients

de Jong, Rolien; Altare, Frédéric; Haagen, Inez-Anne; G. Elferink, Diënne; de Boer, Tjitske; J.C. van Breda Vriesman, Peter; Kabel, Peter; M. T. Draaisma, Johannes; T. van Dissel, Jaap; P. Kroon, Frank; Casanova, Jean‐Laurent; H. M. Ottenhoff, Tom

doi:10.1126/science.280.5368.1435

Public

Severe Mycobacterial and Salmonella Infections in Interleukin-12 Receptor-Deficient Patients

Published in Science • May 29, 1998

Authors:

Rolien de Jong

Frédéric Altare

Inez-Anne Haagen

Abstract

Interleukin-12 (IL-12) is a cytokine that promotes cell-mediated immunity to intracellular pathogens by inducing type 1 helper T cell (TH1) responses and interferon-gamma (IFN-gamma) production. IL-12 binds to high-affinity beta1/beta2 heterodimeric IL-12 receptor (IL-12R) complexes on T cell and na...

Subject

Intracellular

Biology

Extracellular

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