Loss of TGF-β Responsiveness in Prostate Stromal Cells Alters Chemokine Levels and Facilitates the Development of Mixed Osteoblastic/Osteolytic Bone Lesions

Li, Xiaohong; A. Sterling, Julie; Fan, Kang-Hsien; L. Vessella, Robert; Shyr, Yu; W. Hayward, Simon; M. Matrisian, Lynn; A. Bhowmick, Neil

doi:10.1158/1541-7786.mcr-11-0506

Public

Loss of TGF-β Responsiveness in Prostate Stromal Cells Alters Chemokine Levels and Facilitates the Development of Mixed Osteoblastic/Osteolytic Bone Lesions

Published in Molecular Cancer Research • Jan 31, 2012

Authors:

Xiaohong Li

Julie A. Sterling

Kang-Hsien Fan

Abstract

Loss of TGF-β type II receptor (TβRII, encoded by Tgfbr2) expression in the prostate stroma contributes to prostate cancer initiation, progression, and invasion. We evaluated whether TβRII loss also affected prostate cancer bone metastatic growth. Immunohistologic analysis revealed that TβRII expres...

Subject

CXCL1

Stromal cell

Prostate cancer

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