Loss of TGF-β responsiveness in prostate stromal cells alters chemokine levels and facilitates the development of mixed osteoblastic/osteolytic bone lesions.

X, Li; JA, Sterling; KH, Fan; RL, Vessella; Y, Shyr; SW, Hayward; LM, Matrisian; NA, Bhowmick

doi:10.1158/1541-7786.mcr-11-0506

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Loss of TGF-β responsiveness in prostate stromal cells alters chemokine levels and facilitates the development of mixed osteoblastic/osteolytic bone lesions.

Shared by NobleBlocks on Jan 30, 2012 • 12:00 AM UTC

Authors:

Li X

Sterling JA

Fan KH

Abstract

Loss of TGF-β type II receptor (TβRII, encoded by Tgfbr2) expression in the prostate stroma contributes to prostate cancer initiation, progression, and invasion. We evaluated whether TβRII loss also affected prostate cancer bone metastatic growth. Immunohistologic analysis revealed that TβRII expres...

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