Recurrent microdeletions at 15q11.2 and 16p13.11 predispose to idiopathic generalized epilepsies

G. F. de Kovel, Carolien; Trucks, Holger; L. Helbig, Katherine; C. Mefford, Heather; Baker, Carl; Leu, Costin; Kluck, Christian; Muhle, Hiltrud; von Spiczak, Sarah; Ostertag, P; Obermeier, Tanja; A. Kleefuß‐Lie, Ailing; Hallmann, Kerstin; Steffens, Michael; Gaus, Verena; Martin Klein, Karl; M. Hamer, Hajo; Rosenow, Felix; H. Brilstra, Eva; Kasteleijn‐Nolst Trenité, Dorothée; E.M. Swinkels, Mariëlle; Weber, Yvonne; Unterberger, Iris; Zimprich, Fritz; Urak, L; Feucht, Martha; Fuchs, Karoline; S. Møller, Rikke; Hjalgrim, Helle; De Jonghe, Peter; Suls, Arvid; Ruckert, I.-M.; Wichmann, H.‐Erich; Franke, André; Schreiber, S.; Nürnberg, Peter; E. Elger, Christian; Lerche, Holger; Stephani, Ulrich; P.C. Koeleman, Bobby; Lindhout, Dick; E. Eichler, Evan; Sander, T.

doi:10.1093/brain/awp262

Public

Recurrent microdeletions at 15q11.2 and 16p13.11 predispose to idiopathic generalized epilepsies

Published in Brain • Oct 20, 2009

Authors:

Carolien G. F. de Kovel

Holger Trucks

Katherine L. Helbig

Abstract

Idiopathic generalized epilepsies account for 30% of all epilepsies. Despite a predominant genetic aetiology, the genetic factors predisposing to idiopathic generalized epilepsies remain elusive. Studies of structural genomic variations have revealed a significant excess of recurrent microdeletions ...

Subject

Idiopathic generalized epilepsy

Epilepsy

Medicine

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