AMD3100 disrupts the cross-talk between chronic lymphocytic leukemia cells and a mesenchymal stromal or nurse-like cell-based microenvironment: pre-clinical evidence for its association with chronic lymphocytic leukemia treatments

Stamatopoulos, Basile; Meuleman, Nathalie; De Bruyn, C.; Pieters, Karlien; Mineur, Philippe; Le Roy, Christine; Saint-Georges, Stéphane; Varin‐Blank, Nadine; Cymbalista, Florence; Bron, Dominique; Lagneaux, L.

doi:10.3324/haematol.2011.052779

Public

AMD3100 disrupts the cross-talk between chronic lymphocytic leukemia cells and a mesenchymal stromal or nurse-like cell-based microenvironment: pre-clinical evidence for its association with chronic lymphocytic leukemia treatments

Published in Haematologica • Nov 4, 2011

Authors:

Basile Stamatopoulos

Nathalie Meuleman

C. De Bruyn

Abstract

BACKGROUND: Interactions with the microenvironment, such as bone marrow mesenchymal stromal cells and nurse-like cells, protect chronic lymphocytic leukemia cells from spontaneous and drug-induced apoptosis. This protection is partially mediated by the chemokine SDF-1α (CXCL12) and its receptor CXCR...

Subject

Chronic lymphocytic leukemia

Stromal cell

Mesenchymal stem cell

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