Global Histone Modifications in Breast Cancer Correlate with Tumor Phenotypes, Prognostic Factors, and Patient Outcome

Elsheikh, Somaia; R. Green, Andrew; A. Rakha, Emad; G. Powe, Des; A. Ahmed, Rabab; M. Collins, Hilary; Soria, Daniele; M. Garibaldi, Jonathan; E. Paish, Claire; Ammar, Amr; J. Grainge, Matthew; Ball, Graham; K. Abdelghany, Magdy; Martínez‐Pomares, Luisa; M. Heery, David; O. Ellis, Ian

doi:10.1158/0008-5472.can-08-3907

Public

Global Histone Modifications in Breast Cancer Correlate with Tumor Phenotypes, Prognostic Factors, and Patient Outcome

Published in Cancer Research • Apr 14, 2009

Authors:

Somaia Elsheikh

Andrew R. Green

Emad A. Rakha

Abstract

Post-translational histone modifications are known to be altered in cancer cells, and loss of selected histone acetylation and methylation marks has recently been shown to predict patient outcome in human carcinoma. Immunohistochemistry was used to detect a series of histone lysine acetylation (H3K9...

Subject

Breast cancer

Biology

Histone

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