Green Tea Epigallocatechin-3-Gallate (EGCG) Modulates Amyloid Precursor Protein Cleavage and Reduces Cerebral Amyloidosis in Alzheimer Transgenic Mice

Rezai‐Zadeh, Kavon; Shytle, Doug; Sun, Nan; Mori, T.; Hou, Huayan; Jeanniton, Deborah; Ehrhart, Jared; Townsend, Kirk; Zeng, Jin; Morgan, David; Hardy, John; Town, Terrence; Tan, Jun

doi:10.1523/jneurosci.1521-05.2005

Public

Green Tea Epigallocatechin-3-Gallate (EGCG) Modulates Amyloid Precursor Protein Cleavage and Reduces Cerebral Amyloidosis in Alzheimer Transgenic Mice

Published in Journal of Neuroscience • Sep 21, 2005

Authors:

Kavon Rezai‐Zadeh

Doug Shytle

Nan Sun

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder pathologically characterized by deposition of beta-amyloid (Abeta) peptides as senile plaques in the brain. Recent studies suggest that green tea flavonoids may be used for the prevention and treatment of a variety of neurodegenera...

Subject

Amyloid precursor protein

Amyloid precursor protein secretase

Alpha secretase

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