Development and validation of sensitive method for determination of serum cotinine in smokers and nonsmokers by liquid chromatography/atmospheric pressure ionization tandem mass spectrometry

T. Bernert, John; E. Turner, Wayman; L. Pirkle, James; S. Sosnoff, Connie; R. Akins, James; K Waldrep, Mary; Ann, Qinghong; R. Covey, Thomas; Whitfield, Wanda; W. Gunter, Elaine; B. Miller, Barbara; G. Patterson, Donald; L. Needham, Larry; Harry Hannon, W.; J. Sampson, Eric

doi:10.1093/clinchem/43.12.2281

Public

Development and validation of sensitive method for determination of serum cotinine in smokers and nonsmokers by liquid chromatography/atmospheric pressure ionization tandem mass spectrometry

Published in Clinical Chemistry • Dec 1, 1997

Authors:

John T. Bernert

Wayman E. Turner

James L. Pirkle

Abstract

We describe a sensitive and specific method for measuring cotinine in serum by HPLC coupled to an atmospheric pressure chemical ionization tandem mass spectrometer. This method can analyze 100 samples/day on a routine basis, and its limit of detection of 50 ng/L makes it applicable to the analysis o...

Subject

Cotinine

Chromatography

Mass spectrometry

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