An Antibody-Deficiency Syndrome Due to Mutations in the<i>CD19</i>Gene

C. van Zelm, Menno; Reisli, İsmail; van der Burg, Mirjam; Castaño, Diana; J.M. van Noesel, Carel; J. D. van Tol, Maarten; Woellner, Cristina; Grimbacher, Bodo; Javier Patiño Grajales, Pablo; J. M. van Dongen, Jacques; Luis Franco, José

doi:10.1056/nejmoa051568

Public

An Antibody-Deficiency Syndrome Due to Mutations in theCD19Gene

Published in New England Journal of Medicine • May 3, 2006

Authors:

Menno C. van Zelm

İsmail Reisli

Mirjam van der Burg

Abstract

BACKGROUND: The CD19 protein forms a complex with CD21, CD81, and CD225 in the membrane of mature B cells. Together with the B-cell antigen receptor, this complex signals the B cell to decrease its threshold for activation by the antigen. METHODS: We evaluated four patients from two unrelated famili...

Subject

CD19

CD5

Immunophenotyping

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