Identification and characterization of a functional, alternatively spliced Toll-like receptor 7 (TLR7) and genomic disruption of TLR8 in chickens.

VJ, Philbin; M, Iqbal; Y, Boyd; MJ, Goodchild; RK, Beal; N, Bumstead; J, Young; AL, Smith

doi:10.1111/j.1365-2567.2005.02125.x

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Identification and characterization of a functional, alternatively spliced Toll-like receptor 7 (TLR7) and genomic disruption of TLR8 in chickens.

Shared by NobleBlocks on Apr 1, 2005 • 12:00 AM UTC

Authors:

Philbin VJ

Iqbal M

Boyd Y

Abstract

Based upon the recognition of antiviral compounds and single stranded viral RNA the Toll-like receptors TLR7 and TLR8 are suggested to play a significant role in initiating antiviral immune responses. Here we report the molecular characterization of the chicken TLR7/8 loci which revealed an intact T...

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