Adult-Onset Primary Open-Angle Glaucoma Caused by Mutations in Optineurin

Rezaie, Tayebeh; H. Child, Anne; A. Hitchings, Roger; Brice, Glen; Miller, Lauri; Coca‐Prados, Miguel; Héon, Elise; Krupin, Theodore; Ritch, Robert; L. Kreutzer, Donald; P. Crick, Ronald; Sarfarazi, Mansoor

doi:10.1126/science.1066901

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Adult-Onset Primary Open-Angle Glaucoma Caused by Mutations in Optineurin

Published in Science • Feb 8, 2002

Authors:

Tayebeh Rezaie

Anne H. Child

Roger A. Hitchings

Abstract

Primary open-angle glaucoma (POAG) affects 33 million individuals worldwide and is a leading cause of blindness. In a study of 54 families with autosomal dominantly inherited adult-onset POAG, we identified the causative gene on chromosome 10p14 and designated it OPTN (for "optineurin"). Sequence al...

Subject

Optineurin

Trabecular meshwork

Biology

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