Gene Expression Classification of Colon Cancer into Molecular Subtypes: Characterization, Validation, and Prognostic Value

Marisa, Laëtitia; de Reyniès, Aurélien; Duval, Alex; Sèlves, Janick; Pierre Gaub, Marie; Vescovo, Laure; Étienne-Grimaldi, Marie-Christine; Schiappa, Renaud; Guénot, Dominique; Ayadi, Mira; Kirzin, Sylvain; Chazal, M; Fléjou, Jean–François; Benchimol, Daniel; Berger, Anne; Lagarde, Arnaud; Pencreach, Erwan; Piard, F; Élias, Dominique; Parc, Yann; Olschwang, Sylviane; Milano, G.; Laurent‐Puig, Pierre; Boige, Valérie

doi:10.1371/journal.pmed.1001453

Public

Gene Expression Classification of Colon Cancer into Molecular Subtypes: Characterization, Validation, and Prognostic Value

Published in PLoS Medicine • May 21, 2013

Authors:

Laëtitia Marisa

Aurélien de Reyniès

Alex Duval

Abstract

BACKGROUND: Colon cancer (CC) pathological staging fails to accurately predict recurrence, and to date, no gene expression signature has proven reliable for prognosis stratification in clinical practice, perhaps because CC is a heterogeneous disease. The aim of this study was to establish a comprehe...

Subject

KRAS

Microsatellite instability

Biology

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