Distinct Roles of Thioredoxin in the Cytoplasm and in the Nucleus

Hirota, Kiichi; Murata, Miyahiko; Sachi, Yoshifumi; Nakamura, Hajime; S. Takeuchi, Junko; Mori, Kenjiro; Yodoi, Junji

doi:10.1074/jbc.274.39.27891

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Distinct Roles of Thioredoxin in the Cytoplasm and in the Nucleus

Published in Journal of Biological Chemistry • Sep 1, 1999

Authors:

Kiichi Hirota

Miyahiko Murata

Yoshifumi Sachi

Abstract

Oxidative stresses such as UV irradiation to mammalian cells triggers a variety of oxistress responses including activation of transcription factors. Recently, activation of nuclear factor-kappaB (NF-kappaB) has been shown to be under oxidoreduction (redox) regulation controlled by thioredoxin (TRX)...

Subject

Thioredoxin

Cytoplasm

Transcription factor

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