Identification of Genes Upregulated in <i>ALK</i> -Positive and <i>EGFR/KRAS/ALK</i> -Negative Lung Adenocarcinomas

Okayama, Hirokazu; Kohno, Takashi; Ishii, Yuko; Shimada, Yoko; Shiraishi, Kouya; Iwakawa, Reika; Furuta, Koh; Tsuta, Koji; Shibata, Tatsuhiro; Yamamoto, Seiichiro; Watanabe, Shun‐ichi; Sakamoto, Hiromi; Kumamoto, Kensuke; Takenoshita, Seiichi; Gotoh, Noriko; Mizuno, Hideaki; Sarai, Akinori; Kawano, Shuichi; Yamaguchi, Rui; Miyano, Satoru; Yokota, Jun

doi:10.1158/0008-5472.can-11-1403

Public

Identification of Genes Upregulated in ALK -Positive and EGFR/KRAS/ALK -Negative Lung Adenocarcinomas

Published in Cancer Research • Nov 12, 2011

Authors:

Hirokazu Okayama

Takashi Kohno

Yuko Ishii

Abstract

Activation of the EGFR, KRAS, and ALK oncogenes defines 3 different pathways of molecular pathogenesis in lung adenocarcinoma. However, many tumors lack activation of any pathway (triple-negative lung adenocarcinomas) posing a challenge for prognosis and treatment. Here, we report an extensive genom...

Subject

KRAS

Adenocarcinoma

Lung cancer

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