The Novel Oxygenated Chalcone, 2,4‐Dimethoxy‐4'‐Butoxychalcone, Exhibits Potent Activity against Human Malaria ParasitePlasmodium falciparumIn Vitro and Rodent ParasitesPlasmodium bergheiandPlasmodium yoeliiIn Vivo

Chen, M.; Brøgger Christensen, S.; Zhai, L.; Højby Rasmussen, Michael; G. Theander, Thor; Frøkjær, Sven; Steffansen, Bente; Rømhild Davidsen, Jesper; Kharazmi, A.

doi:10.1086/514129

Public

The Novel Oxygenated Chalcone, 2,4‐Dimethoxy‐4'‐Butoxychalcone, Exhibits Potent Activity against Human Malaria ParasitePlasmodium falciparumIn Vitro and Rodent ParasitesPlasmodium bergheiandPlasmodium yoeliiIn Vivo

Published in The Journal of Infectious Diseases • Nov 1, 1997

Authors:

M. Chen

S. Brøgger Christensen

L. Zhai

Abstract

Previous studies have shown that licochalcone A, an oxygenated chalcone, exhibits antileishmanial and antimalarial activities. The present study was designed to examine the antimalarial activity of an analog of licochalcone A, 2,4-dimethoxy-4'-butoxychalcone (2,4mbc). 2,4mbc inhibited the in vitro g...

Subject

Plasmodium berghei

Plasmodium falciparum

Parasitemia

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