The requirement for eukaryotic initiation factor 4A (eIF4A) in translation is in direct proportion to the degree of mRNA 5′ secondary structure

V. Svitkin, Yuri; Pause, Arnim; Haghighat, Ashkan; Pyronnet, Stéphane; W. Witherell, Gary; J. Belsham, Graham; Sonenberg, Nahum

doi:10.1017/s135583820100108x

Public

The requirement for eukaryotic initiation factor 4A (eIF4A) in translation is in direct proportion to the degree of mRNA 5′ secondary structure

Published in RNA • Mar 1, 2001

Authors:

Yuri V. Svitkin

Arnim Pause

Ashkan Haghighat

Abstract

Eukaryotic initiation factor (elF) 4A functions as a subunit of the initiation factor complex elF4F, which mediates the binding of mRNA to the ribosome. elF4A possesses ATPase and RNA helicase activities and is the prototype for a large family of putative RNA helicases (the DEAD box family). It is t...

Subject

Biology

Internal ribosome entry site

Initiation factor

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