Expression of Nicotinic Acetylcholine Receptor Subunit Genes in Non–Small-Cell Lung Cancer Reveals Differences between Smokers and Nonsmokers

Lam, David; Girard, Luc; D. Ramirez, Ruben; Chau, Wing-shun; Suen, Wai-Sing; Sheridan, Shelley; P.C. Tin, Vicky; Chung, Lap‐Ping; Pik Wong, Maria; W. Shay, Jerry; F. Gazdar, Adi; Lam, Wah-kit; D. Minna, John

doi:10.1158/0008-5472.can-06-4628

Public

Expression of Nicotinic Acetylcholine Receptor Subunit Genes in Non–Small-Cell Lung Cancer Reveals Differences between Smokers and Nonsmokers

Published in Cancer Research • May 15, 2007

Authors:

David Lam

Luc Girard

Ruben D. Ramirez

Abstract

Nicotine and its derivatives, by binding to nicotinic acetylcholine receptors (nAChR) on bronchial epithelial cells, can regulate cellular proliferation and apoptosis via activating the Akt pathway. Delineation of nAChR subtypes in non-small-cell lung cancers (NSCLC) may provide information for prev...

Subject

Nicotine

Nicotinic acetylcholine receptor

Cancer research

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