BCL6 suppression of BCL2 via Miz1 and its disruption in diffuse large B cell lymphoma

Saito, Masumichi; Novak, Urban; Piovan, Erich; Basso, Katia; Sumazin, Pavel; Schneider, Christof; Crespo, Marta; Shen, Qiong; Bhagat, Govind; Califano, Andrea; Chadburn, Amy; Pasqualucci, Laura; Dalla‐Favera, Riccardo

doi:10.1073/pnas.0903854106

Public

BCL6 suppression of BCL2 via Miz1 and its disruption in diffuse large B cell lymphoma

Published in Proceedings of the National Academy of Sciences • Jun 23, 2009

Authors:

Masumichi Saito

Urban Novak

Erich Piovan

Abstract

The BCL6 proto-oncogene encodes a transcriptional repressor that is required for germinal center (GC) formation and whose deregulation by genomic lesions is implicated in the pathogenesis of GC-derived diffuse large B cell lymphoma (DLBCL) and, less frequently, follicular lymphoma (FL). The biologic...

Subject

BCL6

Germinal center

Lymphoma

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