Gadolinium-based Contrast Agent Accumulates in the Brain Even in Subjects without Severe Renal Dysfunction: Evaluation of Autopsy Brain Specimens with Inductively Coupled Plasma Mass Spectroscopy

Kanda, Tomonori; Fukusato, Toshio; Matsuda, Megumi; Toyoda, Keiko; Oba, Hiroshi; Kotoku, J.; Haruyama, Takahiro; Kitajima, Kazuhiro; Furui, Shigeru

doi:10.1148/radiol.2015142690

Public

Gadolinium-based Contrast Agent Accumulates in the Brain Even in Subjects without Severe Renal Dysfunction: Evaluation of Autopsy Brain Specimens with Inductively Coupled Plasma Mass Spectroscopy

Published in Radiology • May 5, 2015

Authors:

Tomonori Kanda

Toshio Fukusato

Megumi Matsuda

Abstract

PURPOSE: To use inductively coupled plasma mass spectroscopy (ICP-MS) to evaluate gadolinium accumulation in brain tissues, including the dentate nucleus (DN) and globus pallidus (GP), in subjects who received a gadolinium-based contrast agent (GBCA). MATERIALS AND METHODS: Institutional review boar...

Subject

Medicine

Gadolinium

White matter

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