Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

A. Miller, Richard; E. Harrison, David; M. Astle, Clinton; A. Baur, Joseph; R. Boyd, Angela; de Cabo, Rafael; Fernández, Elizabeth; Flurkey, Kevin; A. Javors, Martin; F. Nelson, James; J. Orihuela, Carlos; D. Pletcher, Scott; Dave Sharp, Z.; Sinclair, David; W. Starnes, Joseph; E. Wilkinson, John; L. Nadon, Nancy; Strong, Randy

doi:10.1093/gerona/glq178

Public

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

Published in The Journals of Gerontology Series A • Oct 25, 2010

Authors:

Richard A. Miller

David E. Harrison

Clinton M. Astle

Abstract

Rapamycin was administered in food to genetically heterogeneous mice from the age of 9 months and produced significant increases in life span, including maximum life span, at each of three test sites. Median survival was extended by an average of 10% in males and 18% in females. Rapamycin attenuated...

Subject

Simvastatin

Life span

Resveratrol

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