Mitochondrial Complex I Inhibitor Rotenone Induces Apoptosis through Enhancing Mitochondrial Reactive Oxygen Species Production

Li, Nianyu; Ragheb, Kathy; Lawler, Gretchen; Sturgis, Jennie; Rajwa, Bartek; Andrés Melendez, J.; Paul Robinson, J.

doi:10.1074/jbc.m210432200

Public

Mitochondrial Complex I Inhibitor Rotenone Induces Apoptosis through Enhancing Mitochondrial Reactive Oxygen Species Production

Published in Journal of Biological Chemistry • Feb 28, 2003

Authors:

Nianyu Li

Kathy Ragheb

Gretchen Lawler

Abstract

Inhibition of mitochondrial respiratory chain complex I by rotenone had been found to induce cell death in a variety of cells. However, the mechanism is still elusive. Because reactive oxygen species (ROS) play an important role in apoptosis and inhibition of mitochondrial respiratory chain complex ...

Subject

Rotenone

Reactive oxygen species

Mitochondrial ROS

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