Common alleles at 6q25.1 and 1p11.2 are associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers

C. Antoniou, Antonis; Kartsonaki, Christiana; M. Sinilnikova, Olga; Soucy, Penny; McGuffog, Lesley; Healey, Sue; Lee, Andrew; Peterlongo, Paolo; Manoukian, Siranoush; Peissel, Bernard; Zaffaroni, Daniela; Cattaneo, Elisa; Barile, Monica; Pensotti, Valeria; Pasini, Barbara; Dolcetti, Riccardo; Giannini, Giuseppe; Laura Putignano, Anna; Varesco, Liliana; Radice, Paolo; L. Mai, Phuong; H. Greene, Mark; L. Andrulis, Irene; Glendon, Gord; Özçelik, Hilmi; Thomassen, Mads; Gerdes, Anne‐Marie; A. Kruse, Torben; Birk Jensen, Uffe; Gylling Crüger, Dorthe; A. Caligo, Maria; Laitman, Yael; Milgrom, Roni; Kaufman, Bella; Paluch–Shimon, Shani; Friedman, Eitan; Loman, Niklas; Harbst, Katja; Lindblom, Annika; Arver, Brita; Ehrencrona, Hans; Melin, Beatrice; , SWE-BRCA; L. Nathanson, Katherine; M. Domchek, Susan; R. Rebbeck, Timothy; Jakubowska, Anna; Lubiński, Jan; Gronwald, Jacek; Huzarski, Tomasz; Byrski, Tomasz; Cybulski, Cezary; Górski, Bohdan; Osório, Ana; Ramón y Cajal, Teresa; Fostira, Florentia; Andrés, Raquel; Benı́tez, Javier; Hamann, Ute; B.L. Hogervorst, Frans; A. Rookus, Matti; J. Hooning, Maartje; Nelen, Marcel; B. van der Luijt, Rob; A.M. van Os, Theo; J. van Asperen, Christi; Devilee, Peter; Meijers‐Heijboer, Hanne; Gómez, E.; , HEBON; Peock, Susan; Cook, Margaret; Frost, Debra; Platte, Radka; Leyland, Jean; Gareth Evans, D.; Lalloo, Fiona; A. Eeles, Rosalind; Izatt, Louise; Adlard, Julian; Davidson, Rosemarie; Eccles, Diana; Ong, Kai-Ren; Cook, Jackie; Douglas, Fiona; Paterson, Joan; J. Kennedy, Michael; Miedzybrodzka, Zosia; , EMBRACE; K. Godwin, Andrew; Stoppa‐Lyonnet, Dominique; Buecher, Bruno; Belotti, Muriel; Tirapo, Carole; Mazoyer, Sylvie; Barjhoux, Laure; Lasset, Christine; Leroux, Dominique; Faivre, Laurence; Bronner, Myriam; Prieur, Fabienne; Noguès, Catherine; Rouleau, Étienne; Pujol, Pascal; Coupier, Isabelle; Frénay, Marc; Study Collaborators, CEMO; L. Hopper, John; B. Daly, Mary; Beth Terry, Mary; M. John, Esther; S. Buys, Saundra; Yassin, Yosuf; Miron, Alexander; E. Goldgar, David; Cancer Family Registry, Breast; F. Singer, Christian; Tea, Muy‐Kheng; Pfeiler, Georg; Catharina Dressler, Anne; van Overeem Hansen, Thomas; Jønson, Lars; Ejlertsen, Bent; B. Barkardóttir, Rósa; Kirchhoff, Tomas; Offit, Kenneth; Piedmonte, Marion; C. Rodriguez, Gustavo; Small, Laurie; F. Boggess, John; V. Blank, Stephanie; Basil, Jack; Azodi, Masoud; E. Toland, Amanda; Montagna, Marco; Tognazzo, Silvia; Agata, Simona; Imyanitov, Evgeny; Janavičius, Ramūnas; Lázaro, Conxi; Blanco, Ignacio; D.P. Pharoah, Paul; Sucheston, Lara; Y. Karlan, Beth; Walsh, Christine; Oláh, Edith; Bozsik, Anikó; Teo, Soo‐Hwang; Seldon, Joyce; Beattie, Mary; J. van Rensburg, Elizabeth; D. Sluiter, Michelle; Dı́ez, Orland; K. Schmutzler, Rita; Wappenschmidt, Barbara; Engel, Christoph; Meindl, Alfons; Ruehl, I.; Varon-Mateeva, Raymonda; Kast, Karin; Deißler, Helmut; Niederacher, Dieter; Arnold, Norbert; Gadzicki, Dorothea; Schönbuchner, Ines; Caldes, Trinidad; de la Hoya, Miguel; Nevanlinna, Heli; Aittomäki, Kristiina; Dumont, Martine; Chiquette, Jocelyne; Tischkowitz, Marc; Chen, Xiaoqing; Beesley, Jonathan; B. Spurdle, Amanda; investigators, kConFab; L. Neuhausen, Susan; Chun Ding, Yuan; Fredericksen, Zachary; Wang, Xianshu; Shane Pankratz, V.; J. Couch, Fergus; Simard, Jacques; F. Easton, Douglas; Chenevix‐Trench, Georgia; behalf of CIMBA, on

doi:10.1093/hmg/ddr226

Public

Common alleles at 6q25.1 and 1p11.2 are associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers

Published in Human Molecular Genetics • May 18, 2011

Authors:

Antonis C. Antoniou

Christiana Kartsonaki

Olga M. Sinilnikova

Abstract

Two single nucleotide polymorphisms (SNPs) at 6q25.1, near the ESR1 gene, have been implicated in the susceptibility to breast cancer for Asian (rs2046210) and European women (rs9397435). A genome-wide association study in Europeans identified two further breast cancer susceptibility variants: rs112...

Subject

Biology

Allele

Genetics

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