Vaccine protection by a triple deletion mutant of simian immunodeficiency virus

S. Wyand, Michael; Manson, Kelledy; Garcia-Moll, M; C. Montefiori, David; C. Desrosiers, Ronald

doi:10.1128/jvi.70.6.3724-3733.1996

Public

Vaccine protection by a triple deletion mutant of simian immunodeficiency virus

Published in Journal of Virology • Jun 1, 1996

Authors:

Michael S. Wyand

Kelledy Manson

M Garcia-Moll

Abstract

Twelve rhesus monkeys were vaccinated with SIVmac316 delta nef (lacking nef sequences), and 12 were vaccinated with SIVmac239 delta3 (lacking nef, vpr, and upstream sequences in U3). SIVmac316 and SIVmac239 differ by only eight amino acids in the envelope; these changes render SIVmac316 highly compe...

Subject

Biology

Virology

Simian immunodeficiency virus

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