Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells

Ménissier de Murcia, Josiane; Niedergang, C.; Trucco, Carlotta; Ricoul, Michèle; Dutrillaux, Bernard; Mark, Manuel; Javier Oliver, F.; Masson, Murielle; Dierich, A.; LeMeur, Marianne; Walztinger, C; Chambon, Pierre; de Murcia, Gilbert

doi:10.1073/pnas.94.14.7303

Public

Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells

Published in Proceedings of the National Academy of Sciences • Jul 8, 1997

Authors:

Josiane Ménissier de Murcia

C. Niedergang

Carlotta Trucco

Abstract

Poly(ADP-ribose) polymerase [PARP; NAD+ ADP-ribosyltransferase; NAD+: poly(adenosine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyltransferase, EC 2.4.2.30] is a zinc-finger DNA-binding protein that detects specifically DNA strand breaks generated by genotoxic agents. To determine its biological func...

Subject

Poly ADP ribose polymerase

Molecular biology

NAD+ kinase

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