Protein kinase‐dependent HPr/CcpA interaction links glycolytic activity to carbon catabolite repression in Gram‐positive bacteria

Deutscher, Josef; Küster-Schöck, Elke; Bergstedt, Uta; Charrier, Véronique; Hillen, Wolfgang

doi:10.1111/j.1365-2958.1995.tb02280.x

Public

Protein kinase‐dependent HPr/CcpA interaction links glycolytic activity to carbon catabolite repression in Gram‐positive bacteria

Published in Molecular Microbiology • Mar 1, 1995

Authors:

Josef Deutscher

Elke Küster-Schöck

Uta Bergstedt

Abstract

CcpA, the repressor/activator mediating carbon catabolite repression and glucose activation in many Gram-positive bacteria, has been purified from Bacillus megaterium after fusing it to a His tag. CcpA-his immobilized on a Ni-NTA resin specifically interacted with HPr phosphorylated at seryl residue...

Subject

Catabolite repression

CCPA

Biology

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