WNK1 Regulates Vasoconstriction and Blood Pressure Response to α <sub>1</sub> -Adrenergic Stimulation in Mice

Bergaya, Sonia; Faure, Sébastien; Baudrie, Véronique; Rio, Marc; Escoubet, Brigitte; Bonnin, Philippe; Henrion, Daniel; Loirand, Gervaise; Achard, Jean‐Michel; Jeunemaı̂tre, Xavier; Hadchouel, Juliette

doi:10.1161/hypertensionaha.111.172429

Public

WNK1 Regulates Vasoconstriction and Blood Pressure Response to α 1 -Adrenergic Stimulation in Mice

Published in Hypertension • Jul 19, 2011

Authors:

Sonia Bergaya

Sébastien Faure

Véronique Baudrie

Abstract

Gain-of-function mutations in the human WNK1 (with-no-lysine[K]1) gene are responsible for a monogenic form of arterial hypertension, and WNK1 polymorphisms have been associated with common essential hypertension. The role of WNK1 in renal ionic reabsorption has been established, but no investigatio...

Subject

Endocrinology

Internal medicine

Vasoconstriction

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