Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer

Seok Ju, Young; B. Alexandrov, Ludmil; Gerstung, Moritz; Martin, Sancha; Nik-Zainal, Serena; Ramakrishna, Manasa; Davies, Helen; Papaemmanuil, Elli; Gundem, Gunes; Shlien, Adam; Bolli, Niccolò; Behjati, Sam; Tarpey, Patrick; Nangalia, Jyoti; Massie, Charles; P. Butler, Adam; W. Teague, Jon; S. Vassiliou, George; R. Green, Anthony; Du, Ming‐Qing; Unnikrishnan, Ashwin; E. Pimanda, John; Tean Teh, Bin; C. Munshi, Nikhil; Greaves, Mel; Vyas, Paresh; K. El‐Naggar, Adel; Santarius, Tom; Peter Collins, V.; G. Grundy, Richard; A. Taylor, Jack; Neil Hayes, D; Malkin, David; Breast Cancer Group, ICGC; Chronic Myeloid Disorders Group, ICGC; Prostate Cancer Group, ICGC; S. Foster, Christopher; Y. Warren, Anne; C. Whitaker, Hayley; S. Brewer, Daniel; A. Eeles, Rosalind; Cooper, Colin; E. Neal, David; Visakorpi, Tapio; B. Isaacs, William; Steven Bova, G.; M. Flanagan, Adrienne; Andrew Futreal, P.; G. Lynch, Andy; F. Chinnery, Patrick; McDermott, Ultan; R. Stratton, Michael; J. Campbell, Peter

doi:10.7554/elife.02935

Public

Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer

Published in eLife • Sep 30, 2014

Authors:

Young Seok Ju

Ludmil B. Alexandrov

Moritz Gerstung

Abstract

Recent sequencing studies have extensively explored the somatic alterations present in the nuclear genomes of cancers. Although mitochondria control energy metabolism and apoptosis, the origins and impact of cancer-associated mutations in mtDNA are unclear. In this study, we analyzed somatic alterat...

Subject

Somatic cell

Mitochondrial DNA

Biology

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!