Transplantation of Human Pericyte Progenitor Cells Improves the Repair of Infarcted Heart Through Activation of an Angiogenic Program Involving Micro-RNA-132

Katare, Rajesh; Riu, Federica; J. Mitchell, Kathryn; Gubernator, Miriam; Campagnolo, Paola; Cui, Yuxin; Fortunato, Orazio; Avolio, Elisa; Cesselli, Daniela; Paolo Beltrami, Antonio; D. Angelini, Gianni; Emanueli, Costanza; Madeddu, Paolo

doi:10.1161/circresaha.111.251546

Public

Transplantation of Human Pericyte Progenitor Cells Improves the Repair of Infarcted Heart Through Activation of an Angiogenic Program Involving Micro-RNA-132

Published in Circulation Research • Aug 26, 2011

Authors:

Rajesh Katare

Federica Riu

Kathryn J. Mitchell

Abstract

RATIONALE: Pericytes are key regulators of vascular maturation, but their value for cardiac repair remains unknown. OBJECTIVE: We investigated the therapeutic activity and mechanistic targets of saphenous vein-derived pericyte progenitor cells (SVPs) in a mouse myocardial infarction (MI) model. METH...

Subject

Angiogenesis

Cell biology

Transplantation

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