RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself

Liddicoat, Brian; Piskol, Robert; M. Chalk, Alistair; Ramaswami, Gokul; Higuchi, Miyoko; C. Hartner, Jochen; Billy Li, Jin; H. Seeburg, Peter; R. Walkley, Carl

doi:10.1126/science.aac7049

Public

RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself

Published in Science • Jul 24, 2015

Authors:

Brian Liddicoat

Robert Piskol

Alistair M. Chalk

Abstract

Adenosine-to-inosine (A-to-I) editing is a highly prevalent posttranscriptional modification of RNA, mediated by ADAR (adenosine deaminase acting on RNA) enzymes. In addition to RNA editing, additional functions have been proposed for ADAR1. To determine the specific role of RNA editing by ADAR1, we...

Subject

RNA editing

ADAR

RNA silencing

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