CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

Liu, Weihong; Putnam, Amy; Xu-yu, Zhou; L. Szot, Gregory; R. Lee, Michael; Zhu, Shirley; A. Gottlieb, Peter; Kapranov, Philipp; Gingeras, T; Fazekas de St Groth, Barbara; Clayberger, Carol; M. Soper, David; F. Ziegler, Steven; A. Bluestone, Jeffrey

doi:10.1084/jem.20060772

Public

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

Published in The Journal of Experimental Medicine • Jul 3, 2006

Authors:

Weihong Liu

Amy Putnam

Zhou Xu-yu

Abstract

Regulatory T (T reg) cells are critical regulators of immune tolerance. Most T reg cells are defined based on expression of CD4, CD25, and the transcription factor, FoxP3. However, these markers have proven problematic for uniquely defining this specialized T cell subset in humans. We found that the...

Subject

Interleukin-7 receptor

IL-2 receptor

FOXP3

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