Randomized Trial of Genotype-Guided Versus Standard Warfarin Dosing in Patients Initiating Oral Anticoagulation

L. Anderson, Jeffrey; D. Horne, Benjamin; M. Stevens, Scott; Grove, Amanda; Barton, Stephanie; P. Nicholas, Zachery; F.S. Kahn, Samera; T. May, Heidi; M. Samuelson, Kent; B. Muhlestein, Joseph; F. Carlquist, John

doi:10.1161/circulationaha.107.737312

Public

Randomized Trial of Genotype-Guided Versus Standard Warfarin Dosing in Patients Initiating Oral Anticoagulation

Published in Circulation • Nov 7, 2007

Authors:

Jeffrey L. Anderson

Benjamin D. Horne

Scott M. Stevens

Abstract

BACKGROUND: Pharmacogenetic-guided dosing of warfarin is a promising application of "personalized medicine" but has not been adequately tested in randomized trials. METHODS AND RESULTS: Consenting patients (n=206) being initiated on warfarin were randomized to pharmacogenetic-guided or standard dosi...

Subject

Medicine

Dosing

Pharmacogenetics

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