Main results of the Ouabain and Adducin for Specific Intervention on Sodium in Hypertension Trial (OASIS-HT): a randomized placebo-controlled phase-2 dose-finding study of rostafuroxin

A. Staessen, Jan; Thijs, Lutgarde; Stolarz‐Skrzypek, Katarzyna; Bacchieri, Antonella; Barton, John; degli Espositi, Ezio; W. de Leeuw, Peter; Dłużniewski, Mirosław; Glorioso, Nicola; Januszewicz, Andrzej; Manunta, Paolo; A. Milyagin, Viktor; Nikitin, Yuri; Souček, Miroslav; Lanzani, Chiara; Citterio, Lorena; Timio, Mario; Tykarski, Andrzej; Ferrari, Paolo; Valentini, Giovanni; Kawecka−Jaszcz, Kalina; Bianchi, Giuseppe

doi:10.1186/1745-6215-12-13

Public

Main results of the Ouabain and Adducin for Specific Intervention on Sodium in Hypertension Trial (OASIS-HT): a randomized placebo-controlled phase-2 dose-finding study of rostafuroxin

Published in Trials • Jan 14, 2011

Authors:

Jan A. Staessen

Lutgarde Thijs

Katarzyna Stolarz‐Skrzypek

Abstract

BACKGROUND: The Ouabain and Adducin for Specific Intervention on Sodium in Hypertension (OASIS-HT) Trial was a phase-2 dose-finding study of rostafuroxin, a digitoxygenin derivative, which selectively antagonizes the effects of endogenous ouabain (EO) on Na+,K+-ATPase and mutated adducin. Rostafurox...

Subject

Placebo

Medicine

Blood pressure

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!