Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy

Brown, Sara; Asai, Yuka; J. Cordell, Heather; Campbell, Linda; Zhao, Yiwei; Liao, Haihui; Northstone, Kate; Henderson, John; Alizadehfar, Reza; Ben‐Shoshan, Moshe; Morgan, Kenneth; Roberts, Graham; J. Masthoff, L.; G.M.A. Pasmans, Suzanne; C. van den Akker, Peter; Wijmenga, Cisca; O’B Hourihane, Jonathan; N.A. Palmer, Colin; Lack, Gideon; E. Clarke, Ann; Hull, Peter; D. Irvine, Alan; Irwin McLean, W.H.

doi:10.1016/j.jaci.2011.01.031

Public

Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy

Published in Journal of Allergy and Clinical Immunology • Mar 1, 2011

Authors:

Sara Brown

Yuka Asai

Heather J. Cordell

Abstract

BACKGROUND: IgE-mediated peanut allergy is a complex trait with strong heritability, but its genetic basis is currently unknown. Loss-of-function mutations within the filaggrin gene are associated with atopic dermatitis and other atopic diseases; therefore, filaggrin is a candidate gene in the etiol...

Subject

Filaggrin

Peanut allergy

Atopic dermatitis

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