Positional Cloning of the Gene for Multiple Endocrine Neoplasia-Type 1

C. Chandrasekharappa, Settara; C. Guru, Siradanahalli; Manickam, Pachiappan; Olufemi, Shodimu-Emmanuel; S. Collins, Francis; R. Emmert‐Buck, Michael; V. Debelenko, Larisa; Zhuang, Zhengping; A. Lubensky, Irina; A. Liotta, Lance; S. Crabtree, Judy; Wang, Ying‐Ping; A. Roe, Bruce; M. Weisemann, Jane; S. Boguski, Mark; Agarwal, Sunita; Beth Kester, Mary; S. Kim, Young; Heppner, Christina; Dong, Qihan; M. Spiegel, Allen; Lee Burns, A.; J. Marx, Stephen

doi:10.1126/science.276.5311.404

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Positional Cloning of the Gene for Multiple Endocrine Neoplasia-Type 1

Published in Science • Apr 18, 1997

Authors:

Settara C. Chandrasekharappa

Siradanahalli C. Guru

Pachiappan Manickam

Abstract

Multiple endocrine neoplasia-type 1 (MEN1) is an autosomal dominant familial cancer syndrome characterized by tumors in parathyroids, enteropancreatic endocrine tissues, and the anterior pituitary. DNA sequencing from a previously identified minimal interval on chromosome 11q13 identified several ca...

Subject

MEN1

Frameshift mutation

Multiple endocrine neoplasia

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