A Mutation in the Interferon-γ –Receptor Gene and Susceptibility to Mycobacterial Infection

J. Newport, Melanie; Huxley, Clare; Huston, Sara; M. Hawrylowicz, Catherine; A. Oostra, Ben; Williamson, Robert; Levin, Michael

doi:10.1056/nejm199612263352602

Public

A Mutation in the Interferon-γ –Receptor Gene and Susceptibility to Mycobacterial Infection

Published in New England Journal of Medicine • Dec 26, 1996

Authors:

Melanie J. Newport

Clare Huxley

Sara Huston

Abstract

BACKGROUND: Genetic differences in immune responses may affect susceptibility to mycobacterial infection, but no specific genes have been implicated in humans. We studied four children who had an unexplained genetic susceptibility to mycobacterial infection and who appeared to have inherited the sam...

Subject

Gene

Genetic predisposition

Mutation

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