Lysophosphatidic Acid‐Induced Neurite Retraction in PC12 Cells: Control by Phosphoinositide‐Ca<sup>2+</sup> Signaling and Rho

Tigyi, Gábor; J. Fischer, David; Sebök, Ágnes; R. Yang, Charles; L. Dyer, David; Miledi, Ricardo

doi:10.1046/j.1471-4159.1996.66020537.x

Public

Lysophosphatidic Acid‐Induced Neurite Retraction in PC12 Cells: Control by Phosphoinositide‐Ca2+ Signaling and Rho

Published in Journal of Neurochemistry • Feb 1, 1996

Authors:

Gábor Tigyi

David J. Fischer

Ágnes Sebök

Abstract

The endogenous phospholipid mediator lysophosphatidic acid (LPA) caused growth cone collapse, neurite retraction, and cell flattening in differentiated PC12 cells. Neurite retraction was blocked by cytochalasin B and ADP-ribosylation of the small-molecular-weight G protein Rho by the Clostridium bot...

Subject

Lysophosphatidic acid

Second messenger system

Neurite

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!