Blockade of IL-6 <i>Trans</i> Signaling Attenuates Pulmonary Fibrosis

T. Le, Thanh‐Thuy; Karmouty‐Quintana, Harry; Melicoff, Ernestina; T. Le, Thanh-Truc; Weng, Tingting; Chen, Ning‐Yuan; Pedroza, Mesias; Zhou, Yang; Davies, Jonathan; Philip, Kemly; G. Molina, Jose; Luo, Fayong; T. George, Anuh; J. Garcia‐Morales, Luis; Bunge, R.R.; A. Bruckner, Brian; Loebe, Matthias; Seethamraju, Harish; K. Agarwal, Sandeep; R. Blackburn, Michael

doi:10.4049/jimmunol.1302470

Public

Blockade of IL-6 Trans Signaling Attenuates Pulmonary Fibrosis

Published in The Journal of Immunology • Aug 30, 2014

Authors:

Thanh‐Thuy T. Le

Harry Karmouty‐Quintana

Ernestina Melicoff

Abstract

Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease with progressive fibrosis and death within 2-3 y of diagnosis. IPF incidence and prevalence rates are increasing annually with few effective treatments available. Inhibition of IL-6 results in the attenuation of pulmonary fibrosis in mice....

Subject

Pulmonary fibrosis

Idiopathic pulmonary fibrosis

Myofibroblast

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