Rituximab in Children with Steroid-Dependent Nephrotic Syndrome

Ravani, Pietro; Rossi, Roberta; Bonanni, Alice; R. Quinn, Robert; Sica, Felice; Bodria, Monica; Pasini, Andrea; Montini, Giovanni; Edefonti, Alberto; Belingheri, Mirco; De Giovanni, Donatella; Barbano, Giancarlo; Degl’Innocenti, Ludovica; Scolari, Francesco; Murer, Luisa; Reiser, Jochen; Fornoni, Alessia; Marco Ghiggeri, Gian

doi:10.1681/asn.2014080799

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Rituximab in Children with Steroid-Dependent Nephrotic Syndrome

Published in Journal of the American Society of Nephrology • Jan 15, 2015

Authors:

Pietro Ravani

Roberta Rossi

Alice Bonanni

Abstract

Steroid-dependent nephrotic syndrome (SDNS) carries a high risk of toxicity from steroids or steroid-sparing agents. This open-label, noninferiority, randomized controlled trial at four sites in Italy tested whether rituximab is noninferior to steroids in maintaining remission in juvenile SDNS. We e...

Subject

Medicine

Rituximab

Prednisone

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