The Molecular Basis of Turcot's Syndrome

R. Hamilton, Stanley; Liu, Bo; Parsons, Ramon; Papadopoulos, Nickolas; Jen, Jin; M. Powell, Steven; J. Krush, Anne; Berk, Theresa; Cohen, Zane; Têtu, Bernard; C. Burger, Peter; A. Wood, Patricia; Taqi, Fowzia; V. Booker, Susan; M. Petersen, Gloria; Johan A. Offerhaus, G.; C. Tersmette, Anne; M. Giardiello, Francis; Vogelstein, Bert; W. Kinzler, Kenneth

doi:10.1056/nejm199503303321302

Public

The Molecular Basis of Turcot's Syndrome

Published in New England Journal of Medicine • Mar 30, 1995

Authors:

Stanley R. Hamilton

Bo Liu

Ramon Parsons

Abstract

BACKGROUND: Turcot's syndrome is characterized clinically by the concurrence of a primary brain tumor and multiple colorectal adenomas. We attempted to define the syndrome at the molecular level. METHODS: Fourteen families with Turcot's syndrome identified in two registries and the family originally...

Subject

Medulloblastoma

Familial adenomatous polyposis

Germline

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