IL-1β Production through the NLRP3 Inflammasome by Hepatic Macrophages Links Hepatitis C Virus Infection with Liver Inflammation and Disease

Negash, Amina; J. Ramos, Hilario; Crochet, Nanette; Lau, Daryl; Doehle, Brian; Papić, Neven; A. Delker, Don; Jo, Juandy; Bertoletti, Antonio; H. Hagedorn, Curt; Gale, Michael

doi:10.1371/journal.ppat.1003330

Public

IL-1β Production through the NLRP3 Inflammasome by Hepatic Macrophages Links Hepatitis C Virus Infection with Liver Inflammation and Disease

Published in PLoS Pathogens • Apr 25, 2013

Authors:

Amina Negash

Hilario J. Ramos

Nanette Crochet

Abstract

Chronic hepatitis C virus (HCV) infection is a leading cause of liver disease. Liver inflammation underlies infection-induced fibrosis, cirrhosis and liver cancer but the processes that promote hepatic inflammation by HCV are not defined. We provide a systems biology analysis with multiple lines of ...

Subject

Inflammasome

Inflammation

Immunology

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!