Ly-6C <sup>high</sup> Monocytes Depend on Nr4a1 to Balance Both Inflammatory and Reparative Phases in the Infarcted Myocardium

Hilgendorf, Ingo; M.S. Gerhardt, Louisa; C. Tan, Timothy; Winter, Carla; A.W. Holderried, Tobias; G. Chousterman, Benjamin; Iwamoto, Yoshiko; Liao, Ronglih; Zirlik, Andreas; Scherer-Crosbie, Marielle; C. Hedrick, Catherine; Libby, Peter; Nahrendorf, Matthias; Weissleder, Ralph; K. Świrski, Filip

doi:10.1161/circresaha.114.303204

Public

Ly-6C high Monocytes Depend on Nr4a1 to Balance Both Inflammatory and Reparative Phases in the Infarcted Myocardium

Published in Circulation Research • Mar 14, 2014

Authors:

Ingo Hilgendorf

Louisa M.S. Gerhardt

Timothy C. Tan

Abstract

RATIONALE: Healing after myocardial infarction involves the biphasic accumulation of inflammatory lymphocyte antigen 6C (Ly-6C)(high) and reparative Ly-6C(low) monocytes/macrophages (Mo/MΦ). According to 1 model, Mo/MΦ heterogeneity in the heart originates in the blood and involves the sequential re...

Subject

Monocyte

Chemokine

Macrophage

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