Achyranthes bidentata extract exerts osteoprotective effects on steroid-induced osteonecrosis of the femoral head in rats by regulating RANKL/RANK/OPG signaling

Jiang, Yini; Zhang, Yanqiong; Chen, Weiheng; Liu, Chunfang; Li, Xiaomin; Sun, Danni; Liu, Zhenli; Xu, Ying; Mao, Xia; Guo, Qiuyan; Lin, Na

doi:10.1186/s12967-014-0334-7

Public

Achyranthes bidentata extract exerts osteoprotective effects on steroid-induced osteonecrosis of the femoral head in rats by regulating RANKL/RANK/OPG signaling

Published in Journal of Translational Medicine • Nov 29, 2014

Authors:

Yini Jiang

Yanqiong Zhang

Weiheng Chen

Abstract

BACKGROUND: Steroid-induced osteonecrosis of the femoral head (steroid-induced ONFH) presents great challenges due to the various effects of steroids on multi-system pathways involved into osteoblast differentiation, osteoblast and osteoclast apoptosis, lipid metabolism, calcium metabolism and coagu...

Subject

RANKL

Osteoprotegerin

Osteoclast

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