Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

Carracedo, Arkaitz; Ma, Li; Teruya‐Feldstein, Julie; Rojo, Federico; Salmena, Leonardo; Alimonti, Andrea; Egia, Ainara; T. Sasaki, Atsuo; Thomas, George; C. Kozma, Sara; Papa, Antonella; Nardella, Caterina; C. Cantley, Lewis; Baselga, José; Paolo Pandolfi, Pier

doi:10.1172/jci34739

Public

Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

Published in Journal of Clinical Investigation • Aug 1, 2008

Authors:

Arkaitz Carracedo

Li Ma

Julie Teruya‐Feldstein

Abstract

Numerous studies have established a causal link between aberrant mammalian target of rapamycin (mTOR) activation and tumorigenesis, indicating that mTOR inhibition may have therapeutic potential. In this study, we show that rapamycin and its analogs activate the MAPK pathway in human cancer, in what...

Subject

mTORC1

MAPK/ERK pathway

PI3K/AKT/mTOR pathway

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