Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling

Felcht, Moritz; Luck, Robert; Schering, Alexander; Seidel, Philipp; Srivastava, Kshitij; Hu, Junhao; Bartol, Arne; Kienast, Yvonne; Vettel, Christiane; K. Loos, Elias; Kutschera, Simone; Bartels, Susanne; Appak‐Baskoy, Sila; Besemfelder, Eva; Terhardt, Dorothee; Chavakis, Emmanouil; Wieland, Thomas; Klein, Christian; Thomas, Markus; Uemura, Akiyoshi; Goerdt, Sergij; G. Augustin, Hellmut

doi:10.1172/jci58832

Public

Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling

Published in Journal of Clinical Investigation • May 15, 2012

Authors:

Moritz Felcht

Robert Luck

Alexander Schering

Abstract

Angiopoietin-2 (ANG-2) is a key regulator of angiogenesis that exerts context-dependent effects on ECs. ANG-2 binds the endothelial-specific receptor tyrosine kinase 2 (TIE2) and acts as a negative regulator of ANG-1/TIE2 signaling during angiogenesis, thereby controlling the responsiveness of ECs t...

Subject

Angiogenesis

Angiopoietin receptor

Angiopoietin

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