Gentamicin-Induced Correction of CFTR Function in Patients with Cystic Fibrosis and<i>CFTR</i>Stop Mutations

Wilschanski, Michael; Yahav, Yaacov; Yaacov, Yasmin; Blau, Hannah; Bentur, Lea; Rivlin, Joseph; Aviram, Micha; Bdolah‐Abram, Tali; Bebők, Zsuzsa; Shushi, Liat; Kerem, Batsheva; Kerem, Eitan

doi:10.1056/nejmoa022170

Public

Gentamicin-Induced Correction of CFTR Function in Patients with Cystic Fibrosis andCFTRStop Mutations

Published in New England Journal of Medicine • Oct 8, 2003

Authors:

Michael Wilschanski

Yaacov Yahav

Yasmin Yaacov

Abstract

BACKGROUND: Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene containing a premature termination signal cause a deficiency or absence of functional chloride-channel activity. Aminoglycoside antibiotics can suppress premature termination codons, thus permitting translat...

Subject

Cystic fibrosis

Medicine

Cystic fibrosis transmembrane conductance regulator

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