Mitochondrial DNA copy number is regulated in a tissue specific manner by DNA methylation of the nuclear-encoded DNA polymerase gamma A

D. Kelly, Richard; Mahmud, Arsalan; McKenzie, Matthew; A. Trounce, Ian; C. St. John, Justin

doi:10.1093/nar/gks770

Public

Mitochondrial DNA copy number is regulated in a tissue specific manner by DNA methylation of the nuclear-encoded DNA polymerase gamma A

Published in Nucleic Acids Research • Aug 31, 2012

Authors:

Richard D. Kelly

Arsalan Mahmud

Matthew McKenzie

Abstract

DNA methylation is an essential mechanism controlling gene expression during differentiation and development. We investigated the epigenetic regulation of the nuclear-encoded, mitochondrial DNA (mtDNA) polymerase γ catalytic subunit (PolgA) by examining the methylation status of a CpG island within ...

Subject

Biology

DNA methylation

Molecular biology

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