Extracellular Matrix Promotes Highly Efficient Cardiac Differentiation of Human Pluripotent Stem Cells

Zhang, Jianhua; Klos, Matthew; F. Wilson, Gisela; M. Herman, Amanda; Lian, Xiaojun; Raval, Kunil; Barron, Matthew; Hou, Luqia; G. Soerens, Andrew; Yu, Junying; P. Palecek, Sean; E. Lyons, Gary; A. Thomson, James; J. Herron, Todd; Jalife, José; J. Kamp, Timothy

doi:10.1161/circresaha.112.273144

Public

Extracellular Matrix Promotes Highly Efficient Cardiac Differentiation of Human Pluripotent Stem Cells

Published in Circulation Research • Aug 22, 2012

Authors:

Jianhua Zhang

Matthew Klos

Gisela F. Wilson

Abstract

RATIONALE: Cardiomyocytes (CMs) differentiated from human pluripotent stem cells (PSCs) are increasingly being used for cardiovascular research, including disease modeling, and hold promise for clinical applications. Current cardiac differentiation protocols exhibit variable success across different...

Subject

Extracellular matrix

Induced pluripotent stem cell

Cell biology

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