A Biocatalytic Henry Reaction—The Hydroxynitrile Lyase from <i>Hevea brasiliensis</i> Also Catalyzes Nitroaldol Reactions

Purkarthofer, Thomas; Gruber, Karl; Gruber‐Khadjawi, Mandana; Waich, Kerstin; Skranc, Wolfgang; Mink, Daniel; Griengl, Herfried

doi:10.1002/anie.200504230

Public

A Biocatalytic Henry Reaction—The Hydroxynitrile Lyase from Hevea brasiliensis Also Catalyzes Nitroaldol Reactions

Published in Angewandte Chemie International Edition • Apr 24, 2006

Authors:

Thomas Purkarthofer

Karl Gruber

Mandana Gruber‐Khadjawi

Abstract

Novel enzyme activity: Biocatalytic Henry reactions with nitromethane and nitroethane yielded the corresponding nitroalcohols with good enantio- and diastereocontrol in the presence of the hydroxynitrile lyase from the tropical rubber tree Hevea brasiliensis. Molecular modeling and deuterated starti...

Subject

Hevea brasiliensis

Nitromethane

Nitroaldol reaction

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!