Cyclophilin A participates in the nuclear translocation of apoptosis-inducing factor in neurons after cerebral hypoxia-ischemia.

Zhu, Changlian; Wang, Xiaoyang; Deinum, Johanna; Huang, Zhiheng; Gao, Jianfeng; Modjtahedi, Nazanine; R Neagu, Martha; Nilsson, Michael; S Eriksson, Peter; Hagberg, Henrik; Luban, Jeremy; Kroemer, Guido; Blomgren, Klas

doi:10.1084/jem.20070193

Public

Cyclophilin A participates in the nuclear translocation of apoptosis-inducing factor in neurons after cerebral hypoxia-ischemia.

Shared by NobleBlocks on Aug 6, 2007 • 12:00 AM UTC

Authors:

Changlian Zhu

Xiaoyang Wang

Johanna Deinum

Abstract

Upon cerebral hypoxia-ischemia (HI), apoptosis-inducing factor (AIF) can move from mitochondria to nuclei, participate in chromatinolysis, and contribute to the execution of cell death. Previous work (Cande, C., N. Vahsen, I. Kouranti, E. Schmitt, E. Daugas, C. Spahr, J. Luban, R.T. Kroemer, F. Gior...

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