Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease

Chen, Chia-Hsiung; Zhou, Weihui; Liu, Shengchun; Deng, Yu; Cai, Fang; Tone, Masahide; Tone, Yukiko; Tong, Yigang; Song, Weihong

doi:10.1017/s1461145711000149

Public

Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease

Published in The International Journal of Neuropsychopharmacology • Feb 18, 2011

Authors:

Chia-Hsiung Chen

Weihui Zhou

Shengchun Liu

Abstract

Elevated levels of β-site APP cleaving enzyme 1 (BACE1) were found in the brain of some sporadic Alzheimer's disease (AD) patients; however, the underlying mechanism is unknown. BACE1 cleaves β-amyloid precursor protein (APP) to generate amyloid β protein (Aβ), a central component of neuritic plaque...

Subject

BACE1-AS

NF-κB

Amyloid precursor protein secretase

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