<i>PGC-1</i> α, A Potential Therapeutic Target for Early Intervention in Parkinson’s Disease

Zheng, Bin; Liao, Zhixiang; J. Locascio, Joseph; A. Lesniak, Kristen; S. Roderick, Sarah; L. Watt, Marla; C. Eklund, Aron; Zhang‐James, Yanli; D. Kim, Peter; A. Hauser, Michael; Grünblatt, Edna; Moran, Linda; Mandel, Silvia; Riederer, Peter; M. Miller, Renee; J. Federoff, Howard; Wüllner, Ullrich; Papapetropoulos, Spyridon; B. H. Youdim, Moussa; Cantuti‐Castelvetri, Ippolita; B. Young, Anne; M. Vance, Jeffery; L. Davis, Richard; C. Hedreen, John; H. Adler, Charles; G. Beach, Thomas; B. Graeber, Manuel; A. Middleton, Frank; Rochet, Jean‐Christophe; R. Scherzer, Clemens

doi:10.1126/scitranslmed.3001059

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PGC-1 α, A Potential Therapeutic Target for Early Intervention in Parkinson’s Disease

Published in Science Translational Medicine • Oct 6, 2010

Authors:

Bin Zheng

Zhixiang Liao

Joseph J. Locascio

Abstract

Parkinson's disease affects 5 million people worldwide, but the molecular mechanisms underlying its pathogenesis are still unclear. Here, we report a genome-wide meta-analysis of gene sets (groups of genes that encode the same biological pathway or process) in 410 samples from patients with symptoma...

Subject

Disease

Parkinson's disease

Medicine

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